继章节2,这篇继续聊聊食用含有多酚的野樱莓有哪些健康益处吧~
多酚的作用
·心脏保护作用:大量研究表明,食用多酚可以限制冠心病的发病率[1][2][3]。动脉粥样硬化是一种慢性炎症性疾病,发生在中型动脉的病变易发区域。动脉粥样硬化病变可能存在并在临床上无声数十年,然后变得活跃并产生病理状况,例如急性心肌梗死、不稳定型心绞痛或心源性猝死。多酚是LDL 氧化的有效抑制剂,这种类型的氧化被认为是动脉粥样硬化发展的关键机制[4]。多酚可能预防心血管疾病的其他机制是抗氧化、抗血小板、抗炎作用以及增加高密度脂蛋白和改善内皮功能[5]。多酚也可能有助于稳定动脉粥样硬化斑块。
·抗癌作用:多酚对人类癌细胞是有保护的作用,并诱导肿瘤数量或抑制其生长[6]。这些影响已在不同部位观察到,包括口腔、胃、十二指肠、结肠、肝脏、肺、乳腺或皮肤。许多多酚,如槲皮素、儿茶素、异黄酮、木脂素、黄烷酮、鞣花酸、红酒多酚、白藜芦醇和姜黄素;它们都在某些模型中显示出保护作用,尽管发现它们的作用机制不同[7]。
·抗糖尿病作用:许多研究报道了多酚的抗糖尿病作用。茶儿茶素的抗糖尿病潜力已被研究[8][9]。
多酚可能通过不同的机制影响血糖,包括抑制葡萄糖在肠道中的吸收或外周组织的吸收。以麦芽糖作为葡萄糖来源,观察到10 mg/kg 饮食剂量的二乙酰化花青素(diacetylated anthocyanins)的降糖作用,但未观察到蔗糖或葡萄糖[10]。这表明这些作用是由于肠道粘膜中α-葡萄糖苷酶的抑制。还观察到儿茶素在约 50 mg/kg 饮食中对大鼠 α-淀粉酶和蔗糖酶的抑制作用。
·抗衰老作用:研究表明,水果和蔬菜中发现的抗氧化/抗炎多酚化合物的组合可能显示出抗衰老化合物的功效[11][12]。
被称为花青素的类黄酮亚群在颜色鲜艳的水果中特别丰富,例如浆果、康科德葡萄和葡萄籽。花青素是水果颜色的原因,它们已被证明具有强大的抗氧化/抗炎活性,以及抑制脂质过氧化和炎症介质环加氧酶 (COX)-1 和 -2[13]。
·神经保护作用:由于多酚本质上具有高度抗氧化性,因此食用它们可能会为神经系统疾病提供保护。据观察,与饮酒较少或根本不喝酒的人相比,每天喝三到四杯葡萄酒的人患痴呆和阿尔茨海默病的几率降低了80%[14]。研究发现,每周至少食用 3 次含有高浓度多酚的水果和蔬菜,可能在延缓阿尔茨海默病众发挥重要作用[15]。因为水果和蔬菜中的多酚会影响和调节多种细胞过程,如信号传导、增殖、细胞凋亡、氧化还原平衡和分化。
除此之外,多酚还显示出其他几种有益健康的影响。其中包括膳食多酚在治疗哮喘方面起到预防作用[16]。
茶中存在的多酚,当口服或局部使用时,可以改善紫外线照射后的不良皮肤反应,包括皮肤损伤、红斑和脂质过氧化[17]。红茶多酚有助于肠道对矿物质的吸收,并具有抗病毒活性[18]。
文献
[1] Renaud S, de Lorgeril M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet. 1992;339: 1523–1526. [PubMed]
[2] Dubick MA, Omaye ST. Evidence for grape, wine and tea polyphenols as modulators of atherosclerosis and ischemic heart disease in humans. J Nutraceut Functional & Med Foods. 2001;3:67–93. [Google Scholar]
[3] Nardini M, Natella F, Scaccini C. Role of dietary polyphenols in platelet aggregation. A review of the supplementation studies. Platelets. 2007;18:224–243. [PubMed]
[4] Aviram M, Dornfeld L, Rosenblat M, Volkova N, Kaplan M, Coleman R, Hayek T, Presser D, Fuhrman B. Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: Studies in humans and in atherosclerotic apolipoprotein E-deficient mice. Am J Clin Nutr. 2000;71:1062–1076. [PubMed]
[5] García-Lafuente A, Guillamón E, Villares A, Rostagno MA, Martínez JA. Flavonoids as antiinflammatory agents: implications in cancer and cardiovascular disease. Inflamm Res. 2009;58:537–552. [PubMed]
[6] Yang CS, Landau JM, Huang MT, Newmark HL. Inhibition of carcinogenesis by dietary polyphenolic compounds. Ann Rev Nutr. 2001;21:381–406. [PubMed]
[7] Johnson IT, Williamson G, Musk SRR. Anticarcinogenic factors in plant foods: A new class of nutrients? Nutr Res Rev. 1994;7:175–204. [PubMed]
[8] Rizvi SI, Zaid MA, Anis R, Mishra N. Protective role of tea catechins against oxidation-induced damage of type 2 diabetic erythrocytes. Clin Exp Pharmacol Physiol. 2005;32:70–75. [PubMed]
[9] Rizvi S I, Zaid M A. Insulin like effect of epicatechin on membrane acetylcholinesterase activity in type 2 diabetes mellitus. Clin Exp Pharmacol Physiol. 2001;28:776–778. [PubMed]
[10] Matsui T, Ebuchi S, Kobayashi M, Fukui K, Sugita K, Terahara N, Matsumoto K. Anti-hyperglycemic effect of diacylated anthocyanin derived from Ipomoea batatas cultivar Ayamurasaki can be achieved through the alpha-glucosidase inhibitory action. J Agric Food Chem. 2002;50:7244–7248. [PubMed]
[11] Cao G, Booth S L, Sadowsky J A, Prior R L. Increases in human plasma antioxidant capacity after consumption of controlled diets high in fruit and vegetables. Am J Clin Nutr. 1998;68:1081–1087. [PubMed]
[12] Joseph JA, Shukitt-Hale B, Casadesus G. Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds. Am J Clin Nutr. 2005;81:313–316. [PubMed]
[13] Seeram NP, Cichewicz R H, Chandra A, Nair MG. Cyclooxygenase inhibitory and antioxidant compounds from crabapple fruits. J Agric Food Chem. 2003;51:1948–1951. [PubMed]
[14] Scarmeas N, Luchsinger J A, Mayeux R, Stern Y. Mediterranean diet and Alzheimer disease mortality. Neurology. 2007;69:1084–1093. doi: 10.1212/01.wnl.0000277320.50685.7c. [DOI] [PMC free article]
[15] Dai Q, Borenstein AR, Wu Y, Jackson JC, Larson EB. Fruit and vegetable juices and Alzheimer's disease: the Kame Project. Am J Med 2. 2006;119:751–759. doi: 10.1016/j.amjmed.2006.03.045. [DOI] [PMC free article]
[16] Tabak C, Arts ICW, Smit HA, Heederik D, Kromhout D. Chronic obstructive pulmonary disease and intake of catechins, flavonols, and flavones. The MORGEN study. Am J Respir Crit Care Med. 2001;164:61–64. doi: 10.1164/ajrccm.164.1.2010025. [DOI] [PubMed]
[17] Kim J, Hwang JS, Cho YK, Han Y, Jeon YJ, Yang KH. Protective effects of (-)-epigallocatechin-3-gallate on UVAand UVB-induced skin damage. Skin Pharmacol Appl Skin Physiol. 2001;14:11–19. doi: 10.1159/000056329. [DOI] [PubMed]
[18] Sharma V, Rao LJ. A thought on the biological activities of black tea. Crit Rev Food Sci Nutr. 2009;49:379–404. doi: 10.1080/10408390802068066. [DOI] [PubMed]